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BOSTON — Ratio Therapeutics has signed a 17,000-square-foot office lease expansion in Boston’s Seaport District. The developer of radiopharmaceuticals for cancer patients will remain at the Innovation & Design Building, a 1.4 million-square-foot mixed-use property that was originally constructed in 1918 as a waterside storehouse for the South Boston Army Base. Ratio Therapeutics was self-represented in the lease negotiations. A partnership between Related Beal and Jamestown owns the building.