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HOUSTON — Cushman & Wakefield has arranged a $4.5 million loan for the refinancing of Two Harbor Square, a 26,670-square-foot medical office building in Houston. The property was 94.5 percent leased at the time of the loan closing. Tyler Morss of Cushman & Wakefield arranged the loan through Amegy Bank on behalf of the owner, Miami-based healthcare investment firm Creative Equities.