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NEW YORK CITY — Fisher Brothers has signed B. Riley Financial to a 29,173-square-foot lease at 299 Park Avenue in Midtown Manhattan. The property is one of Fisher Brothers’ signature buildings. Los Angeles-based B. Riley, a full-service investment bank, signed a 10-year lease to occupy the entire 21st floor of the 42-story building. The building, which was constructed in 1967, occupies the full block between 48th and 49th streets. B. Riley was represented by Jared Horowitz and Justin Pollner of Newmark Knight Frank in the transaction. Fisher Brothers was represented in-house by Marc Packman and Charles P. Laginestra. 299 Park Avenue is now 90 percent leased.