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NEW YORK CITY — Knotel, a provider of flexible office space, has signed a lease to open a 14,160-square-foot office space at 101 Fifth Avenue, an office building in Manhattan that is owned by Eretz Group. The space will span two floors at the 11-story property and raises Knotel’s total footprint across the city to 40 locations totaling 580,881 square feet. Greg DiGioia and Michael Morris of Newmark Knight Frank represented Knotel in the lease negotiations.