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NEW YORK CITY — Law firm Pollack, Pollack, Isaac & DeCicco has signed a 16,375-square-foot office lease at 250 Broadway in Lower Manhattan. The 648,000-square-foot building recently underwent a lobby remodel and expansion. Anne Holker, Charles Borrok, Jonathan Fales, Frank Cento, Jonathan Fein and Michelle Mean of Cushman & Wakefield represented the landlord, AmTrust RE, in the lease negotiations. Eric Zemachson of Newmark represented the tenant.