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NEW YORK CITY — Pacific College of Oriental Medicine has signed a 42,000-square-foot, 15-year office lease at 110 William St. in Brooklyn. The educational institution for East Asian medicine will occupy the entire 19th floor, plus a portion of the ground floor. Jonathan Dean, senior vice president and director of commercial leasing for Swig Equities, represented the landlord in the transaction. Mark Weiss, Robert Eisenberg and Nick Berger from Newmark Grubb Knight Frank represented the tenant. The 32-story office building spans 900,000 square feet and was 99 percent leased at the time of sale.