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CHICAGO — Iterum Therapeutics US Limited, a subsidiary of Iterum Therapeutics, has signed a 10,318-square-foot office lease at 200 S. Wacker Drive in Chicago to relocate its American headquarters. The Ireland-based pharmaceutical company develops anti-infectives aimed at combatting multi-drug resistant pathogens. The U.S. subsidiary of Iterum Therapeutics is relocating from 200 W. Monroe St. Geoffrey Kasselman, Matthew Whipple, Bob Chodos and Steve Levitas of Newmark Knight Frank represented the tenant in the lease transaction. John Hancock Real Estate owns the building.